Mathematical modeling of biofilms

MRC Dental Group, University of Bristol Dental Hospital, United Kingdom.

A set of mathematical equations constitutes a mathematical model if it aims to represent a real system and is based on some theory of that system's operation. On this definition, mathematical models, some very simple, are everywhere in science. A complex system like a biofilm requires modeling by numerical methods and, because of inevitable uncertainties in its theoretical basis, may not be able to make precise predictions. Nevertheless, such models almost always give new insight into the mechanisms involved, and stimulate further investigation. The way in which diffusion coefficients are measured for use in a model, particularly whether they include effects of reversible reaction, is a key element in the modeling. Reasons are given for separating diffusion from reversible reaction effects and dealing with them in a separate subroutine of the model.