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Department of Oral Biology, Umea University, Sweden.
Dental biofilms could have a structure which, in sections, looks like tissue. The internal structure of the dental biofilm could be the result of interbacterial adhesion mechanisms in combination with nutritional conditions characterized by multiple nutrient starvation. The preservation of the structure of the biofilm over time may also involve the ability of the bacteria to withstand environmental stresses such as starvation, reactive oxygen products, and acid. The present review will describe, first, the regulation of the metabolic defense against environmental stresses and then focus mainly on the energy metabolism of dental biofilms.
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