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Chemotaxis of Cells Isolated from Periodontal Tissues to Different Biological Response Modifiers

V. P. Terranova 1, and U. M.E. Wikesjö 1

1 Department of Oral Biology, State University of New York at Buffalo, School of Dental Medicine, Buffalo, New York 14214

Directed migration of many different cell types is necessary for uneventful wound healing to occur. From clinical periodontal regeneration procedures, it is commonly believed that periodontal ligament cells will be of critical importance in obtaining a new connective tissue attachment. Here we present data which indicate that extracellular matrix components (fibronectin) and polypeptide growth factors (FGF, TGF-alpha, and TGF-beta) modulate the ability of periodontal ligament cells to express directed migration. These data indicate a potential role for matrix components and growth factors in clinical periodontal regenerative procedures.






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IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
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