The Origin of Periodontal Infections

¹ Departments of Oral Biology and Periodontology and Periodontal Disease Clinical Research Center, State University of New York at Buffalo, Foster Hall Buffalo, New York 14214

Periodontal diseases are recognized as bacterial infections, and some forms are associated with specific organisms, such as Actinobacillus actinomycetemcomitans in juvenile periodontitis, and Bacteroides gingivalis and others in adult periodontitis. The source of the periodontal organisms, whether they are part of the indigenous or resident flora and overgrow to become opportunistic oral pathogens, or whether they are exogenous oral pathogens, is important to determine. The chain of periodontal infection, microbial agent(s) and their transmission, and host response are reviewed with respect to the role of A. actinomycetemcomitans in localized juvenile periodontitis and B. gingivalis in adult periodontitis. The present data lead us to hypothesize that some periodontal organisms may be exogenous pathogens.

Prevention of periodontal diseases may be influenced by the knowledge of whether various forms are caused by opportunistic organisms or exogenous pathogens. If exogenous pathogens are responsible, prevention can be directed to intercepting transmission, thereby preventing colonization. On the other hand, if the organisms are opportunistic pathogens, prevention might be directed at interfering with initial acquisition of the flora earlier in life, as well as suppressing them to low levels consistent with health. For those exogenous periodontal infections, attempts at eradication and prevention of re-infection are likely to be effective. If the organisms are part of the indigenous flora, there is little hope of complete elimination of the organism.

Criteria for distinguishing exogenous periodontal pathogens from opportunistic periodontal pathogens include the prediction that exogenous pathogens would be transient members of the oral flora associated with periodontal disease, likely to be comprised of one or a few clonal types, and intrinsically virulent. In contrast, opportunistic periodontal pathogens would likely be members of the indigenous flora and would overgrow. They would likely be comprised of many clonal types, and have an intrinsically low level of virulence.

Note:

The authors thank Drs. Per Brandtzaeg, Boris Albini, Jeff Ebersole, Mogens Kilian, and Else Theilade for critical discussions leading to the definitions of exogenous and opportunistic pathogens, and the indigenous flora, and to establishing criteria for distinguishing exogenous from opportunistic pathogens. We thank the staff of the State University of New York at Buffalo Periodontal Disease Clinical Research Center for their role in the clinical studies. Special appreciation is expressed to Mrs. Rose Parkhill for her expert help in preparing this manuscript.

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