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Inductive Effect of Human Recombinant Il-1 on Differentiation of A Macrophagelike Tumor Cell Line

S. Hanazawa 1, S. Amano 1, C. Hanaizumi 2, K. Hirose 1, Y. Ohmori 1, T. Miyoshi 1, , and S. Kitano 1

1 Department of Oral Microbiology, Josai Dental University, Keyakidai, Sakado City, Saitama, Japan
2 Department of Veterinary Virology, Nihon University School of Veterinary Medicine, Kameino, Fujisawa City, Kanagawa, Japan

We used the macrophage-like tumor cell line P388D1 to test whether interleukin-1 (IL-1) stimulates differentiation of osteoclast-like progenitors. Recombinant human interleukin-1 (rhIL-1) alpha inhibited cell growth in a dose-dependent fashion. Incubation of the cells with rhIL-1 alpha resulted in adherence, stimulation of non-specific esterase activity, and increased Fc receptor expression. These results suggest the possibility that IL-1 may be involved in the differentiation of osteoclast progenitors and thus may be an important local factor in the mechanism of bone resorption.

Note:

We are grateful to Dainippon Pharmaceutical Co. Ltd. for their generous gifts of rhIL-1 alpha and its antiserum.






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IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
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