Advances in Dental Research, Vol 7, 175-181, Copyright © 1993 by International & American Associations for Dental Research

ARTICLES

Diagnostic potential of host response mediators

S. Offenbacher, J. G. Collins and P. A. Heasman
Dental Research Center, University of North Carolina at Chapel Hill 27599.

This review summarizes the data which relate the validation and application of host response markers as diagnostic tests for periodontal diseases. Practical considerations regarding the general application and evaluation of a diagnostic test for periodontal disease are presented. Experiments which have documented the performance of host response markers as diagnostic measures of disease activity in terms of sensitivity, specificity, and predictive values are summarized. Particular emphasis is placed on the diagnostic potential of gingival crevicular fluid (GCF) components. The considerable body of evidence supporting the potential application of GCF-PGE2 levels for predicting episodes of disease progression and reflecting disease activity is summarized and placed into perspective for the development of future diagnostic tools.

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